In collaboration with Wah Chiu’s lab, we’re pushing the limits of cryo-EM single-particle analysis to solve structures. An article in Nature Communications describes our results on a 40 kDa RNA, the SAM-IV riboswitch aptamer. The paper includes analyses confirming that the ligand-binding site can be detected in the RNA. Come play the Eterna puzzle celebrating this beautiful molecule (worth 500 points)
