Improving the stability of RNA vaccines will be important for worldwide vaccine distribution. We present a biophysical model for predicting RNA degradation in a new preprint led by Hannah Wayment-Steele. Through a variety of mRNA design challenges launched through the OpenVaccine challenge on Eterna by Do Soon Kim, we predict that the stability of any RNA vaccine can be increased at least two-fold either through rational design, as demonstrated by Eterna participants, or algorithmically, through the algorithms RiboTree (developed by Christian Choe) and LinearDesign.
