We’re excited to publish our cryo-EM structure of the frameshift stimulation element of the SARS-CoV-2 RNA genome in Nature Structure and Molecular Biology. This work appeared on bioRxiv in 2020, and the new paper includes improved antisense oligonucleotide that target this intricate RNA fold. Thanks to many labs, including those of Jeff Glenn, Wah Chiu, Tim Sheahan, Ralph Baric, and Victoria D’Souza, for this collaboration! You can read more about our work to rapidly solve RNA structures with Wah Chiu at this SLAC piece that also includes the Tetrahymena ribozyme.
