Author: pendari1090

There are many conserved and likely structured elements of the SARS-CoV-2 genome, such as those identified in a previous preprint, with no known 3D structure, which nonetheless may be useful targets for small molecule therapeutics. Ramya Rangan and Andy Watkins have performed studies with our latest structure prediction code, FARFAR2, to make publicly available collections of de novo 3D models of these elements. Their linked preprint has been made available in bioRxiv.

There are many conserved and likely structured elements of the SARS-CoV-2 genome, such as those identified in a previous preprint, with no known 3D structure, which nonetheless may be useful targets for small molecule therapeutics. Ramya Rangan and Andy Watkins have performed studies with our latest structure prediction code, FARFAR2, to make publicly available collections of de novo 3D models of these elements. Their linked preprint has been made available in bioRxiv.

There are many conserved and likely structured elements of the SARS-CoV-2 genome, such as those identified in a previous preprint, with no known 3D structure, which nonetheless may be useful targets for small molecule therapeutics. Ramya Rangan and Andy Watkins have performed studies with our latest structure prediction code, FARFAR2, to make publicly available collections of […]

To aid in the design of nucleic acid-based therapeutics for the raging COVID-19 pandemic, Ramya Rangan and Ivan (Vanya) Zheludev have worked quickly to conduct a comprehensive conservation analysis of the SARS-CoV-2 genome. Their preprint, published today in bioRxiv, identifies in this RNA virus many highly conserved sequences and secondary structure. A follow-up analysis confirms the conservation of many of these regions in the 739 SARS-CoV-2 genomes published during the current outbreak. The regions they have identified provide promising targets for the development of antiviral anti-sense oligonucleotide treatments as we continue to fight the COVID-19 pandemic.

To aid in the design of nucleic acid-based therapeutics for the raging COVID-19 pandemic, Ramya Rangan and Ivan (Vanya) Zheludev have worked quickly to conduct a comprehensive conservation analysis of the SARS-CoV-2 genome. Their preprint, published today in bioRxiv, identifies in this RNA virus many highly conserved sequences and secondary structure. A follow-up analysis confirms the conservation of many of these regions in the 739 SARS-CoV-2 genomes published during the current outbreak. The regions they have identified provide promising targets for the development of antiviral anti-sense oligonucleotide treatments as we continue to fight the COVID-19 pandemic.

To aid in the design of nucleic acid-based therapeutics for the raging COVID-19 pandemic, Ramya Rangan and Ivan (Vanya) Zheludev have worked quickly to conduct a comprehensive conservation analysis of the SARS-CoV-2 genome. Their preprint, published today in bioRxiv, identifies in this RNA virus many highly conserved sequences and secondary structure. A follow-up analysis confirms the conservation of many of […]

We are proud to launch Eterna’s OpenVaccine challenge. These puzzle seeks improved mRNA sequences for COVID-19 vaccines, with a special focus to stabilizing these molecules against degradation to help enable their deployment for mass immunization. Experimental tests are being carried out in collaboration with Maria Barna’s lab in Stanford Genetics. Come join us!

We are proud to launch Eterna’s OpenVaccine challenge. These puzzle seeks improved mRNA sequences for COVID-19 vaccines, with a special focus to stabilizing these molecules against degradation to help enable their deployment for mass immunization. Experimental tests are being carried out in collaboration with Maria Barna’s lab in Stanford Genetics. Come join us!

We are proud to launch Eterna’s OpenVaccine challenge. These puzzle seeks improved mRNA sequences for COVID-19 vaccines, with a special focus to stabilizing these molecules against degradation to help enable their deployment for mass immunization. Experimental tests are being carried out in collaboration with Maria Barna’s lab in Stanford Genetics. Come join us! https://www.youtube.com/watch?v=pGMu569jkEc

Our laboratory won the overall prize in the Kornberg memorial Biochemistry department baking contest , for the second year in a row! In addition, Ramya Rangan won first place in the pie category for her blueberry pie, rotation student Jon Doenier took the cake with his chocolate mousse cake, Vanya Zheludhev directed this year’s skit video, and Matt Adrianowycz MC-ed the winning ceremonies. Happy holidays to all and to the entire department!

Our laboratory won the overall prize in the Kornberg memorial Biochemistry department baking contest , for the second year in a row! In addition, Ramya Rangan won first place in the pie category for her blueberry pie, rotation student Jon Doenier took the cake with his chocolate mousse cake, Vanya Zheludhev directed this year’s skit video, and Matt Adrianowycz MC-ed the winning ceremonies. Happy holidays to all and to the entire department!

Our laboratory won the overall prize in the Kornberg memorial Biochemistry department baking contest , for the second year in a row! In addition, Ramya Rangan won first place in the pie category for her blueberry pie, rotation student Jon Doenier took the cake with his chocolate mousse cake, Vanya Zheludhev directed this year’s skit video, and Matt Adrianowycz MC-ed the winning ceremonies. […]

In collaboration with Wah Chiu’s lab, we’re pushing the limits of cryo-EM single-particle analysis to solve structures. An article in Nature Communications describes our results on a 40 kDa RNA, the SAM-IV riboswitch aptamer. The paper includes analyses confirming that the ligand-binding site can be detected in the RNA. Come play the Eterna puzzle celebrating this beautiful molecule (worth 500 points)

In collaboration with Wah Chiu’s lab, we’re pushing the limits of cryo-EM single-particle analysis to solve structures. An article in Nature Communications describes our results on a 40 kDa RNA, the SAM-IV riboswitch aptamer. The paper includes analyses confirming that the ligand-binding site can be detected in the RNA. Come play the Eterna puzzle celebrating this beautiful molecule (worth 500 points)

In collaboration with Wah Chiu’s lab, we’re pushing the limits of cryo-EM single-particle analysis to solve structures. An article in Nature Communications describes our results on a 40 kDa RNA, the SAM-IV riboswitch aptamer. The paper includes analyses confirming that the ligand-binding site can be detected in the RNA. Come play the Eterna puzzle celebrating this beautiful molecule (worth 500 points)

After a successful pilot experiments in early 2019, Eterna is releasing Ribosome Challenge Round 1

After a successful pilot experiments in early 2019, Eterna is releasing Ribosome Challenge Round 1

After a successful pilot experiments in early 2019, Eterna is releasing Ribosome Challenge Round 1. The goal of this challenge is to create a superfolder variant of the E. coli ribosome whose assembly might be less fragile to mutations or changed solution conditions. If achieved, such a molecule could help worldwide efforts to repurpose the ribosome […]

Congratulations to Kalli Kappel for winning the American Chemical Society’s 2019 Chemical Computing Group excellence award for graduate students. She will be presenting at the ACS meeting in San Diego in late August, on a hybrid method for rapid experimental RNA structure determination called Ribosolve

Congratulations to Kalli Kappel for winning the American Chemical Society’s 2019 Chemical Computing Group excellence award for graduate students. She will be presenting at the ACS meeting in San Diego in late August, on a hybrid method for rapid experimental RNA structure determination called Ribosolve

Congratulations to Kalli Kappel for winning the American Chemical Society’s 2019 Chemical Computing Group excellence award for graduate students. She will be presenting at the ACS meeting in San Diego in late August, on a hybrid method for rapid experimental RNA structure determination called Ribosolve

The fifth annual EternaCon was held at Stanford University on July 20-21 2019! Much of our lab was there as we discuss the next ambitious moonshots for this exciting project. Check out the schedule of events at http://eternawiki.org/wiki/index.php5/Eternacon.

The fifth annual EternaCon was held at Stanford University on July 20-21 2019! Much of our lab was there as we discuss the next ambitious moonshots for this exciting project. Check out the schedule of events at http://eternawiki.org/wiki/index.php5/Eternacon.

The fifth annual EternaCon was held at Stanford University on July 20-21 2019! Much of our lab was there as we discuss the next ambitious moonshots for this exciting project. Check out the schedule of events at http://eternawiki.org/wiki/index.php5/Eternacon.

Rhiju spoke at the 2019 Synthetic Biology: Engineering, Evolution & Design (SEED) in the “Cell Free Synthetic Biology” session on June 23-27, 2019. The topic: a new kind of molecular calculator developed to enable inexpensive diagnostics for active tuberculosis, sepsis, and other diseases tied to ratiometric gene signatures.

Rhiju spoke at the 2019 Synthetic Biology: Engineering, Evolution & Design (SEED) in the “Cell Free Synthetic Biology” session on June 23-27, 2019. The topic: a new kind of molecular calculator developed to enable inexpensive diagnostics for active tuberculosis, sepsis, and other diseases tied to ratiometric gene signatures.

Rhiju spoke at the 2019 Synthetic Biology: Engineering, Evolution & Design (SEED) in the “Cell Free Synthetic Biology” session on June 23-27, 2019. The topic: a new kind of molecular calculator developed to enable inexpensive diagnostics for active tuberculosis, sepsis, and other diseases tied to ratiometric gene signatures.